Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice
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چکیده
منابع مشابه
Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice
Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non-syndromic hydrocephalus. To investigate functions of the tight junction-associated protein Mpdz, we generated mouse models. Global Mpdz gene deletion or conditional inactivation in Nestin-positive cells led to formation of supratentorial hydrocephalus in the early postnata...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2017
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201606430